BSD-2000 Published Clinical Studies

Phase I, II & III Clinical Studies that used the BSD-2000

Tumor Author Year Method No. of Patients Title Journal Abstract Link
Abdominal Angele 2014 CT+HT 149 Effectiveness of Regional Hyperthermia With Chemotherapy for High-Risk Retroperitoneal and Abdominal Soft-Tissue Sarcoma After Complete Surgical Resection Ann Surg Onc icon 48 article
Abdominal Cho 2007 CT+HT 45 Regional hyperthermia of the abdomen in conjunction with chemotherapy for peritoneal carcinomatosis: Evaluation of two annular-phased-array
applicators
Int J Hyperthermia icon 48 article
Tumor Author Year Method No. of Patients Title Journal Abstract Link
Breast Stoetzer 2020 CT+HT 53 Post-Neoadjuvant Gemcitabine and Cisplatin with Regional Hyperthermia for Patients with Triple-Negative Breast Cancer and Non-pCR after Neoadjuvant Chemotherapy: A Single-Institute Experience Karger icon 48 article
Breast De-Colle 2019 RT+HT 20 Hyperthermic chest wall re-irradiation in recurrent breast cancer: a prospective observational study Strahlenther Onkol icon 48 article
Breast Hehr 2001 HT # Thermoradiotherapy for locally recurrent breast cancer with skin involvement Int J Hyperthermia icon 48 article
Tumor Author Year Method No. of Patients Title Journal Abstract Link
Bladder Wen 2021 CT+HT 43 Loco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer Int J Hyperthermia icon 48 article
Bladder Merten 2019 RCT+HT 369 Long-Term Experience of Chemoradiotherapy Combined
with Deep Regional Hyperthermia for Organ Preservation
in High-Risk Bladder Cancer
The Oncologist icon 48 article
Bladder Datta 2019 CRT+HT 16 A Pilot Study of Radiotherapy and Local Hyperthermia in Elderly Patients With Muscle-Invasive Bladder Cancers Unfit for Definitive Surgery or Chemoradiotherapy Front Oncol icon 48 article
Bladder Inman 2014 CT+HT 15 A pilot clinical trial of intravesical mitomycin-C and external deep pelvic hyperthermia for non-muscle-invasive bladder cancer Int J Hyperthermia icon 48 article
Bladder Juang 2014 CT+HT 14 Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer Int J Hyperthermia icon 48 article
Bladder Wittlinger 2009 RCT+HT 45 Quadrimodal treatment of high-risk T1 and T2 bladder cancer: Transurethral tumor resection followed by concurrent radiochemotherapy and regional deep hyperthermia icon 48 article
Bladder Van der Zee 2000 MMC+RT vs.
RT+HT
101 Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group  Lancet icon 48 article
Tumor Author Year Method No. of Patients Title Journal Abstract Link
Cervical Kroesen 2019 RT+HT 400 The Effect of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in 400 Locally Advanced Cervical Carcinoma Patients Front Oncol icon 48 article
Cervical Franckena 2012 RT+HT 498 Review of radiotherapy and hyperthermia in primary cervical cancer Int J Hyperthermia icon 48 article
Cervical Westermann 2012 RT+HT 68 Long-term survival data of triple modality treatment of stage IIB-III-IVA cervical cancer with the combination of radiotherapy, chemotherapy and hyperthermia - an update. Int J Hyperthermia icon 48 article
Cervical Heijkoop 2012 RCT+HT 43 Neoadjuvant chemotherapy followed by radiotherapy and concurrent hyperthermia in patients with advanced-stage cervical cancer: a retrospective study Int J Hyperthermia icon 48 article
Cervical Van der Zee 2010 RCT+HT 6 studies Combined use of hyperthermia and radiation therapy for
treating locally advanced cervical carcinoma
Cochrane Database Syst Rev icon 48 article
Cervical Franckena 2009 CDDP+HT 47 Weekly systemic cisplatin plus locoregional hyperthermia: An effective treatment for patients with recurrent cervical carcinoma in a previously irradiated area Int J Hyperthermia icon 48 article
Cervical Franckena 2009 RT+HT 420 Hyperthermia dose-effect relationship in 420 patients with cervical cancer treated with combined radiotherapy and hyperthermia Eur J Cancer icon 48 article
Cervical Franckena 2009 RT vs.
RT+HT
378 Radiotherapy and hyperthermia for treatment of primary locally advanced cervix cancer: results in 378 patients IJRO icon 48 article
Cervical Franckena 2008 RT vs.
RT+HT
114 Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the Dutch Deep Hyperthermia Trial.  IJRO icon 48 article
Cervical Van der Zee 2006 RT+HT 114 Cervical cancer: Radiotherapy and hyperthermia Int J Hyperthermia icon 48 article
Cervical Sreenivasa 2006 RCT+HT 32 Radiochemotherapy combined with regional pelvic hyperthermia induces high response and resectability rates in patients with nonresectable cervical cancer > or =FIGO IIB "bulky". IJRO icon 48 article
Cervical Westermann 2005 RCT+HT 68 First results of triple-modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with stage IIB, III, and IVA cervical carcinoma. Cancer icon 48 article
Cervical Jones 2003 RT+HT 12 A pilot Phase II trial of concurrent radiotherapy, chemotherapy, and hyperthermia for locally advanced cervical carcinoma. Cancer icon 48 article
Cervical Van der Zee 2001 RT vs.
RT+HT
114 The Dutch Deep Hyperthermia Trial: results in cervical cancer Int J Hyperthermia icon 48 article
Cervical Van der Zee  2001 RT vs.
RT+HT
114 Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group Lancet icon 48 article
Cervical de Wit 1999 CT+HT 19 A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix. Br J Radiol icon 48 article
Tumor Author Year Method No. of Patients Title Journal Abstract Link
Ovarian Fotopoulou 2010 CT+HT 36 Regional abdominal hyperthermia combined with systemic chemotherapy for the treatment of patients with ovarian cancer relapse: Results of a pilot study Int J Hyperthermia icon 48 article
Ovarian Jones 2006 CT+HT 41 Intra-peritoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma Int J Hyperthermia icon 48 article
Ovarian Secord 2005 CT+HT 30 Phase I/II trial of intravenous Doxil and whole abdomen hyperthermia in patients with refractory ovarian cancer. Int J Hyperthermia icon 48 article
Ovarian Hahn 2004 CT+HT 32 Prospective assessment of quality of life in ovarian cancer patients receiving whole abdomen hyperthermia and liposomal doxorubicin. Int J Hyperthermia icon 48 article
Tumor Author Year Method No. of Patients Title Journal Abstract Link
Pancreatic Rogers 2021 CRT+HT 9 The addition of deep hyperthermia to gemcitabine-based chemoradiation may achieve enhanced survival in unresectable locally advanced adenocarcinoma of the pancreas Clin Transl Radiat Oncol icon 48 article
Pancreatic He 2019 CT+HT 17 Modified-FOLFIRINOX combined with deep regional hyperthermia in pancreatic cancer: a retrospective study in Chinese patients Int J Hyperthermia icon 48 article
Pancreatic Tschoep-Lechner 2013 CT+HT 23 Gemcitabine and cisplatin combined with regional hyperthermia as second-line treatment in patients with gemcitabine-refractory advanced pancreatic cancer. Int J Hyperthermia icon 48 article
Pancreatic  Maluta 2011  RCT+HT  68 Regional hyperthermia combined with chemoradiotherapy in primary or recurrent locally advanced pancreatic cancer: an open-label comparative cohort trial Strahlenther Onkol icon 48 article 
Tumor Author Year Method No. of Patients Title Journal Abstract Link
Pediatric Sarcomas Seifert 2016 CT+HT 10 Regional hyperthermia combined with chemotherapy in paediatric, adolescent and young adult patients: current and future perspectives Radiat Oncol icon 48 article
Pediatric Germ Cell Wessalowski 2014 HT 44 Regional deep hyperthermia for salvage treatment of children and adolescents with refractory or recurrent non-testicular malignant germ-cell tumours: an open-label, non-randomised, single-institution, phase 2 study. Lancet Oncol icon 48 article
Pediatric Germ Cell Wessalowski 2003 CT+HT 39 An approach for cure: PEI-chemotherapy and regional deep hyperthermia in children and adolescents with unresectable malignant tumors Klin Padiatr icon 48 article
Germ Cell Schneider 2001 CT+HT 22 Treatment of recurrent malignant sacrococcygeal germ cell tumors: analysis of 22 patients registered in the German protocols MAKEI 83/86, 89, and 96. JCO icon 48 article
Pediatric Germ Cell Wessalowski 1998 CT+HT 10 Hyperthermia for the treatment of patients with malignant germ cell tumors: a phase I/II study in ten children and adolescents with recurrent or refractory tumors Cancer icon 48 article
Germ Cell Tumor Wessalowski 1997 CT+HT 9 Treatment results in children and adolescents with loco-regional recurrences of abdominal germ cell tumors (GCTs): a pilot-study with PEI chemotherapy and regional deep hyperthermia (RHT) in comparison to a matched cohort Klin Padiatr icon 48 article
Tumor Author Year Method No. of Patients Title Journal Abstract Link
Vaginal Aktas 2007 RT+HT 44 Concomitant radiotherapy and hyperthermia for primary carcinoma of the vagina: a cohort study. Eur J Obstet icon 48 article
Pelvic van der Zee 2000 RCT+HT 358 Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial Lancet icon 48 article
Deep Tumors Myerson 1996 RT+HT 66 A phase I/II study to evaluate radiation therapy and hyperthermia for deep-seated tumours: a report of RTOG 89-08. Int J Hyperthermia icon 48 article
Genitourinary

Petrovich

1991 RT vs.
RT+HT
53 Regional hyperthermia in patients with recurrent genitourinary cancer. Am J Clin Oncol icon 48 article
Tumor Author Year Method No. of Patients Title Journal Abstract Link
Prostate Beck 2021 RT+HT 52 Salvage-Radiation Therapy and Regional Hyperthermia for Biochemically Recurrent Prostate Cancer after Radical Prostatectomy Cancers icon 48 article
Prostate Protocol Müller 2015 HT # Regional hyperthermia and moderately dose-escalated salvage radiotherapy for recurrent prostate cancer. Protocol of a phase II trial Radiat Oncol icon 48 article
Prostate Hurwitz 2009 RT+HT 37 Hyperthermia combined with radiation in the treatment of locally advanced prostate cancer is associated with a favourable toxicity profile Int J Hyperthermia   icon 48 article
Prostate Maluta 2007 CRT+HT 144 Conformal radiotherapy plus local hyperthermia in patients affected by locally advanced high risk prostate cancer: preliminary results of a prospective phase II study <Int J Hyperthermia icon 48 article
Prostate Tilly 2005 RT+HT 22 Regional hyperthermia in conjunction with definitive radiotherapy against recurrent or locally advanced prostate cancer T3 pN0 M0. Strahlenther Onkol icon 48 article
Prostate Kalapurakal 2003 RT+HT 13 Efficacy of irradiation and external hyperthermia in locally advanced, hormone-refractory or radiation recurrent prostate cancer: a preliminary report. IJRO icon 48 article
Prostate Kalapurakal 2001 RT+HT 3 Re-irradiation and external hyperthermia in locally advanced, radiation recurrent, hormone refractory prostate cancer: a preliminary report. Br J Radiol icon 48 article 
Prostate Anscher 1997 RT+HT 30 Combined external beam irradiation and external regional hyperthermia for locally advanced adenocarcinoma of the prostate. IJRO icon 48 article
Prostate Kaplan 1991 RT+HT 6 Secondary external-beam radiotherapy and hyperthermia for local recurrence after 125-iodine implantation in adenocarcinoma of the prostate IJRO icon 48 article
Tumor Author Year Method No. of Patients Title Journal Abstract Link
Rectal Ott 2021 CRT+HT 111 Neoadjuvant Chemoradiation Combined with Regional Hyperthermia in Locally Advanced or Recurrent Rectal Cancer Cancers icon 48 article
Rectal Gani 2021 RCT+HT 78 Deep regional hyperthermia with preoperative radiochemotherapy in locally advanced rectal cancer, a prospective phase II trial Radiother Oncol icon 48 article
Anal Ott 2018 CRT+HT 112 Chemoradiotherapy with and without deep regional hyperthermia for squamous cell carcinoma of the anus Strahlenther Onkol icon 48 article
Rectal Zwirner 2017 RCT+HT 86 External validation of a rectal cancer outcome prediction model with a cohort of patients treated with preoperative radiochemotherapy and deep regional hyperthermia Int J Hyperthermia icon 48 article
Rectal Gani 2016 HT 103 Long-term local control and survival after preoperative radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer Int J Hyperthermia icon 48 article
Rectal Schroeder 2012 RCT vs.
RCT+HT
106 Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone. Int J Hyperthermia icon 48 article
Rectal Maluta 2010 RCT+HT 76 Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum Int J Hyperthermia icon 48 article
Rectal Milani 2008 RCT+RHT 24 Radiochemotherapy in combination with regional hyperthermia in preirradiated patients with recurrent rectal cancer Strahlenther Onkol icon 48 article
Rectal Hildebrandt 2004 RT+HT 9 Regional pelvic hyperthermia as an adjunct to chemotherapy (oxaliplatin, folinic acid, 5-fluorouracil) in pre-irradiated patients with locally recurrent rectal cancer: a pilot study. Int J Hyperthermia icon 48 article
Rectal Juffermans 2003 RT+HT 54 Reirradiation and hyperthermia in rectal carcinoma: a retrospective study on palliative effect. Cancer icon 48 article
Rectal Schaffer 2003 RCT+HT 14 Feasibility and Morbidity of Combined Hyperthermia and Radiochemotherapy in Recurrent Rectal Cancer – Preliminary Results Onkologie icon 48 article
Rectal Romano 2003 RT+HT 57 Pre-operative radio-chemotherapy plus regional hyperthermia in the treatment of advanced rectal cancer: experience with radiation dose escalation IJRO icon 48 article
Rectal Anscher 2000 CT+HT 15 A pilot study of preoperative continuous infusion 5-fluorouracil, external microwave hyperthermia, and external beam radiotherapy for treatment of locally advanced, unresectable, or recurrent rectal cancer. IJRO icon 48 article
Rectal Rau 2000 RCT+HT 54 Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters. IJRO icon 48 article
Rectal Van der Zee 2000 RT vs.
RT+HT
143 Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group Lancet icon 48 article
Tumor Rau 1998 RCT+HT 37 Preoperative Hyperthermia Combined with Radiochemotherapy in Locally Advanced Rectal Cancer - A Phase 11 Clinical Trial Ann Surg icon 48 article
Tumor Author Year Method No. of Patients Title Journal Abstract Link
Soft Tissue Sarcoma Lindner 2021 HT # Perioperative chemotherapy and regional hyperthermia for high-risk adult-type soft tissue sarcomas  Eur J Cancer icon 48 article
Soft Tissue Sarcoma Issels 2021 CT+HT 109 Immune infiltrates in patients with localised high-risk soft tissue sarcoma treated with neoadjuvant chemotherapy without or with regional hyperthermia: A translational research program of the EORTC 62961-ESHO 95 randomised clinical trial  Eur J Cancer icon 48 article
Soft Tissue Sarcoma Issels 2020 HT 109 Systemic antitumor effect by regional hyperthermia combined with low-dose chemotherapy and immunologic correlates in an adolescent patient with rhabdomyosarcoma – a case report  Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Bücklein 2020 ICE+HT 110 Ifosfamide, Carboplatin, and Etoposide (ICE) in Combination with Regional Hyperthermia as Salvage Therapy in Patients with Locally Advanced Nonmetastatic and Metastatic Soft-Tissue Sarcoma  Sarcoma icon 48 article
Soft Tissue Sarcoma Aklan 2019 HT # Regional deep hyperthermia: quantitative evaluation of predicted and direct measured temperature distributions in patients with high-risk extremity soft-tissue sarcoma  Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Zschaeck 2018 CT+HT 61 Neoadjuvant chemotherapy plus radiation versus chemotherapy plus regional hyperthermia in high-grade soft tissue sarcomas: a retrospective comparison  Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Issels 2018 CT vs.
CT+HT
341 Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma: The EORTC 62961-ESHO 95 Randomized Clinical Trial.  JAMA icon 48 article
Soft Tissue Sarcoma Eckert 2017 CT+HT 42 Radiotherapy and hyperthermia with curative intent in recurrent high risk soft tissue sarcomas   Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Angele 2014 CT vs.
CT+HT
341 Effectiveness of regional hyperthermia with chemotherapy for high-risk retroperitoneal and abdominal soft-tissue sarcoma after complete surgical resection: a subgroup analysis of a randomized phase-III multicenter study. Ann Surg Oncol icon 48 article
Soft Tissue Sarcoma Issels 2010 CT vs.
CT+HT
341 Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Lancet icon 48 article
Soft Tissue Sarcoma Schlemmer 2010 RCT+HT 47 Thermochemotherapy in patients with extremity high-risk soft tissue sarcomas (HR-STS) Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Fiegl 2004 CT+HT  20 Ifosfamide, carboplatin and etoposide (ICE) as second-line regimen alone and in combination with regional hyperthermia is active in chemo-pre-treated advanced soft tissue sarcoma of adults. Int J Hyperthermia icon 48 article
Soft Tissue Sarcoma Wendtner 2002 CT+HT 58 Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas. JCO icon 48 article
Soft Tissue Sarcoma Issels 2001 CT+HT 59 Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults: long-term results of a phase II study. Eur J Cancer icon 48 article
Soft Tissue Sarcoma Wendtner 2001 RCT+HT 54 Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia. Eur J Cancer icon 48 article
Soft Tissue Sarcoma Prosnitz 1999 RT+HT 97 The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy. IJRO icon 48 article
Soft Tissue Sarcoma Scully 1994 RT+HT 40 Clinical outcome after neoadjuvant thermoradiotherapy in high grade soft tissue sarcomas J Surg Oncol icon 48 article
Soft Tissue Sarcoma Issels 1990 CT+HT 40 Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally advanced sarcomas: a phase II study. JCO icon 48 article

RT-Radiotherapy; HT-Hyperthermia; LHT-Local Hyperthermia; CHT-Chemothyperthermia; CTX-Chemotherapy; MMC-Mitomycin C; EHT; Endocavity Hyperthermia; IHT-Interstitial Hyperthermia; HIPEC-Heated Intraperitoneal Chemotherapy; RCT-RadioChemotherapy; BCG-Bacillus Calmette-Guerin; CRT-Conformal Radiotherapy

Subject Author Year Method No. of Patients Title Journal Abstract Link
SWOT / TOWS Datta 2020 HT # Integrating Loco-Regional Hyperthermia Into the Current Oncology Practice: SWOT and TOWS Analyses Front Oncol icon 48 article
Guideline Bruggmoser 2012 HT # Guideline for the clinical application, documentation and analysis of clinical studies for regional deep hyperthermia Quality management in regional deep hyperthermia Strahlenther Onkol icon 48 article
Study Review Sauer 2010 RT+HT # Concerning the final report “Hyperthermia: a systematic review” of the Ludwig Boltzmann Institute for Health Technology Assessment, Vienna, March 2010 Strahlenther Onkol icon 48 article
Treatment Study Puchinger 2009 HT 27 Psychological and systemic stress reactions of patients during hyperthermia treatments Int J Hyperthermia icon 48 article
MRI Thermometry Gellermann 2009 HT # Methods and potentials of magnetic resonance imaging for monitoring radiofrequency hyperthermia in a hybrid system Int J Hyperthermia icon 48 article
Thermometry Wust 2006 HT # Thermal monitoring: Invasive, minimal-invasive and non-invasive approaches Int J Hyperthermia icon 48 article
Thermometry van Rhoon 2005 HT # Introduction: Non-invasive thermometry for thermotherapy Int J Hyperthermia icon 48 article
MRI Thermometry Wust 2004 HT 33 Part-Body Hyperthermia with a Radiofrequency Multiantenna Applicator under Online Control in a 1.5 T MR-Tomograph Rofo icon 48 article
Study Review Hehr 2003 RCT+HT # Current and Potential Role of Thermoradiotherapy for Solid Tumours Onkologie icon 48 article
Rationale van de Zee 2002 HT # Heating the patient: a promising approach? Ann Oncol icon 48 article
SAR Tilly 2001 HT # Temperature data and specific absorption rates in pelvic tumours: predictive factors and correlations. Int J Hyperthermia icon 48 article
Thermal Dose Maguire 2001 HT # A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy Int J Hyperthermia icon 48 article
Applicator Comparison Feldmann 1993 HT # Deep regional hyperthermia: comparison between the annular phased array and the sigma-60 applicator in the same patients. IJRO icon 48 article
Technical Study Myerson 1991 HT # Phantom studies and preliminary clinical experience with the BSD 2000 Int J Hyperthermia icon 48 article