BSD-2000 Published Clinical Studies

Phase I, II & III Clinical Studies that used the BSD-2000

Tumor Author Year Method No. of Patients Title Journal Abstract Link
Rectal Ott 2021 CRT+HT 111 Neoadjuvant Chemoradiation Combined with Regional Hyperthermia in Locally Advanced or Recurrent Rectal Cancer Cancers icon 48 article
Rectal Gani 2021 RCT+HT 78 Deep regional hyperthermia with preoperative radiochemotherapy in locally advanced rectal cancer, a prospective phase II trial Radiother Oncol icon 48 article
Anal Ott 2018 CRT+HT 112 Chemoradiotherapy with and without deep regional hyperthermia for squamous cell carcinoma of the anus Strahlenther Onkol icon 48 article
Rectal Zwirner 2017 RCT+HT 86 External validation of a rectal cancer outcome prediction model with a cohort of patients treated with preoperative radiochemotherapy and deep regional hyperthermia Int J Hyperthermia icon 48 article
Rectal Gani 2016 HT 103 Long-term local control and survival after preoperative radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer Int J Hyperthermia icon 48 article
Rectal Schroeder 2012 RCT vs.
106 Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone. Int J Hyperthermia icon 48 article
Rectal Maluta 2010 RCT+HT 76 Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum Int J Hyperthermia icon 48 article
Rectal Milani 2008 RCT+RHT 24 Radiochemotherapy in combination with regional hyperthermia in preirradiated patients with recurrent rectal cancer Strahlenther Onkol icon 48 article
Rectal Hildebrandt 2004 RT+HT 9 Regional pelvic hyperthermia as an adjunct to chemotherapy (oxaliplatin, folinic acid, 5-fluorouracil) in pre-irradiated patients with locally recurrent rectal cancer: a pilot study. Int J Hyperthermia icon 48 article
Rectal Juffermans 2003 RT+HT 54 Reirradiation and hyperthermia in rectal carcinoma: a retrospective study on palliative effect. Cancer icon 48 article
Rectal Schaffer 2003 RCT+HT 14 Feasibility and Morbidity of Combined Hyperthermia and Radiochemotherapy in Recurrent Rectal Cancer – Preliminary Results Onkologie icon 48 article
Rectal Romano 2003 RT+HT 57 Pre-operative radio-chemotherapy plus regional hyperthermia in the treatment of advanced rectal cancer: experience with radiation dose escalation IJRO icon 48 article
Rectal Anscher 2000 CT+HT 15 A pilot study of preoperative continuous infusion 5-fluorouracil, external microwave hyperthermia, and external beam radiotherapy for treatment of locally advanced, unresectable, or recurrent rectal cancer. IJRO icon 48 article
Rectal Rau 2000 RCT+HT 54 Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters. IJRO icon 48 article
Rectal Van der Zee 2000 RT vs.
143 Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group Lancet icon 48 article
Tumor Rau 1998 RCT+HT 37 Preoperative Hyperthermia Combined with Radiochemotherapy in Locally Advanced Rectal Cancer - A Phase 11 Clinical Trial Ann Surg icon 48 article