Hyperthermia Blog

News and Opinions About Our Industry

In a new study from the University Hospital at LMU Munich, clinicians looked to improve outcomes for patients with triple-negative breast cancer. According to breastcancer.org, Triple-negative breast cancer is cancer that tests negative for estrogen receptors, progesterone receptors, and excess HER2 protein. These results mean the growth of the cancer is not fueled by the hormones estrogen and progesterone, or by the HER2 protein. Approximately 10-20% of breast cancers are triple-negative breast cancer and is common in women under the age of 40, who are African-descent, or who have a BRACA1 mutation.

“Patients with triple-negative primary breast cancer (TNBC) who have residual invasive carcinoma after neoadjuvant chemotherapy have poor prognosis.” - study quote

The study was offered to 53 patients from August 2012 to January 2019. In the study, patients received six treatment cycles of chemotherapy and 12 applications of regional hyperthermia using the BSD-2000 Deep Regional Hyperthermia System.

Link to article abstract here. https://www.karger.com/Article/Abstract/507473

The University of Maryland Medical Center offers a new Trilogy of Radiation Oncology program at their downtown Baltimore facility.  The cancer center, first in the world to provide proton therapy and hyperthermia under one roof, offers the best in cancer treatment technologies to patients. With the addition of the Gammapod treatment system for early-stage breast cancer, the UMMC maintains it's standing as a leader in patient care.

Pyrexar Medical is privileged to have its BSD-2000 Deep Regional Hyperthermia System and BSD-500 Superficial/Interstitial Hyperthermia System in the hands of these medical pioneers. Many advancements and best practices have come from the pioneering work of the Translational Radiation Science Team at the university.

UPDATE: The ESTRO and WCB conference dates have been pushed back as a precaution to travel-related health risks in neighboring European countries. 

World Congress of Brachytherapy 2020 and the European Society for Radiotherapy and Oncology ESTRO 2020, will be held at the Reed Meese Congress Center, Vienna, Austria this year,  April 2-4, 2020July 31st to August 4th.  Together they provide a broad spectrum of lectures, exhibits, and information on the state of radiotherapy treatment.   Pyrexar will be represented in both events by Sennewald Medizintechnik GmbH.  


UCSF-Predicting Benefit from Advanced Radiation Technologies

On March 27th-29th, the Department of Radiation Oncology, University of California San Francisco School of Medicine, will offer a CME Course titled "Predicting Benefit from Advanced Radiation Technologies."  The 3-day event will cover a vast array of radiotherapy topics, including two presentations on hyperthermia's role in radiation oncology.  Pyrexar is supporting this event with a sponsorship.  - UCSF Event Registration Link

German Cancer Congress

The German Cancer Congress (DKK / Deutscher Krebskongress) is the largest and oldest congress covering cancer diagnostics and therapy in German-speaking countries. The 34th annual congress will take place from February 19th - 22nd, 2020, at the CityCube in Berlin. Thermal oncology experts, Dr. Sennewald Medizintechnik, will be exhibiting Pyrexar's hyperthermia system solutions in booth D1.5 in hall B.

If you are planning on attending, please make a note to attend Hyperthermia Interdisciplinary Working Group (IAH) session titled: Hyperthermia - Indications and Combinations, on Saturday, February 22nd, 2020

CHAIRS: Daniel Zips MD, UMC Tubingen, Germany
Felix Krummradt, UMC Heidelberg, Germany
Peter Wust MD
UMC Charité Berlin
"Current state of technology and relevant studies."
Oliver Ott MD
UMC Erlangen
"Neoadjuvant radiochemotherapy with regional hyperthermia in rectal cancer (HyRec phase II study)"
Cihan Gani MD
UMC Tubingen
"Hyperthermia as part of organ-preserving therapy concepts for rectal cancer."
Rolf Isssels MD
UMC Munich Grosshadern
"Interim analysis of the HEAT phase III study on adjuvant therapy for pancreatic cancer."
Udo Gaipl PhD
UMC Erlangen
"Hyperthermia and immune response."

A complete schedule of events is available on the organization's website.

Pyrexar Medical is a proud sponsor of the Eleventh Biennial Conference of the IAHOM ( Indian Association of Hyperthermic Oncology and Medicine) held in Mumbai on 15th & 16th February 2020. The meeting is co-sponsored by the Society for Cancer Research and Communication and Nanavati Multispeciality Hospital.

Nanavati Hospital Vile Parle Mumbai

Topics at the conference include

    • Immunology relevant to Hyperthermia
    • Nanotechnology
    • Economics of setting up Hyperthermia Center in Emerging Economies
    • Hyperthermia from India HIPEC and HIFU
    • Innovations in Technology

 You may recognize several of the hyperthermia luminaries scheduled to speak which include, Dr. Zeljko Vujaskovic of the University of Maryland Medical Center, Dr. Jacoba van der Zee, Dr. Gerard van Rhoon, and Dr. Hans Creeze of Erasmus MC, The Netherlands, 

Indian association of hyperthermic oncology and medicinenanvati logo .Society of Cancer Research and Communication

A special thanks to Dr. Nagraj G. Hiulgol and Dr. Jugna Bhattacharya for their work in bringing hyperthermia awareness and education to India.

 Link to the conference brochure download.

 

Our friends at Thermosome continue to move their drug targeting platform forward. In a recent video, (shown below) they describe the development of their drug targeting system using focal heat as the release trigger.


BSD-2000 3D/MR makes an appearance at 01:03

Thermosome has developed a drug release system that targets the tumor with a 10 to 15 times higher local drug concentration over standard delivery. They do this by micro-encapsulating approved chemo drugs with a shell of thermosensitive liposomes (TSL). The TSL encapsulated drug is circulated via IV to the patient during the thermal therapy treatment, only releasing it when the surrounding environment reaches 42˚C, which is 5˚C higher than average body temperature.  

thermosome video

Deep Regional Hyperthermia plays an important role by creating the necessary 42˚C microenvironment around the tumor. Combining Thermosome with the BSD-2000 3D/MR provides stable temperatures in a defined focal region.  Additional patient benefit is derived from the positive thermal effects of increased blood flow and perfusion at the tumor site, the immune modulation generated by heating, and the increased concentration of chemotherapeutics.  The visual aspect of the MRI guidance (3D heat zone mapping) offers operator assurance that the tumor area is entirely at the target temperature when the drug is administered. 

Thermosome is actively looking for partners, learn more about at http://www.thermosome.com/

Hanoi High Tech and Digestive Center at the St. Paul Hospital in Vietnam launches its thermal oncology program with the assistance of Dr. Mark Hurwitz. In the photo above, Dr. Hurwitz is explaining the functions of the thermal mapping probe of the newly installed BSD-2000 3D deep regional hyperthermia system.

High Tech Digestive Center Hanoi Vietnam

Saint Paul General Hospital opened the Digestive Center in 2017, specializing in endoscopic surgery and the treatment of digestive disease including stomach and pelvic cancers. Built following European standards, it is the country’s leading endoscopic surgery facility.

Oncology team at High Tech Digestive Center, St. Paul Hospital, Vietnam

Dr. Hurwitz was invited to lecture on hyperthermia best practices and share his vast knowledge and experiences in the field of thermal oncology and its role in cancer treatment.

Thermal oncology training High Tech Digestive Center, St. Paul Hospital, Vietnam

Dr. Hurwitz is a globally known thermal oncologist and radiation oncologist. He is currently Vice-Chair for Quality, Safety & Performance Excellence, and Director of Thermal Oncology, Department of Radiation Oncology, at Jefferson Health, Sidney Kimmel Medical College.

Control center of a BSD-2000 3D system at High Tech Digestive Center, St. Paul Hospital, Vietnam

Often a featured lecturer at conferences throughout the U.S., Europe, and Asia, his hands-on clinical knowledge of both deep regional and superficial thermal therapy prepares new sites, like St. Paul, to become leaders in this cancer treatment technology.

A special thanks to Pyrexar Medical Vietnam distributor Thai Thinh Medical for sponsoring this event. 

The University Hospital Campus Bio-Medico Rome announced the opening of its new thermal oncology unit with the acquisition of two new Linacs and two new hyperthermia treatment systems.  The hospital chose the Pyrexar BSD-500 Superficial/Interstitial System and a BSD-2000 Deep Regional Hyperthermia System to improve cancer treatment. In an article published in the Corriere Della Sera, the hospital shared the following reasons for investing in hyperthermia, a vital cancer treatment technology.

  • tumor oxygenation
  • inhibition of DNA repair
  • anti-tumor immune response
  • enhanced efficacy
  • low toxicity
  • painless and non-invasive

biomedico italy 2000 2a

A special thanks to our distributor, Tema Sinergie, for their excellent representation and continuing efforts in expanding hyperthermia throughout Italy.

Pyrexar Medical exhibited at the PTCOG-NA (Particle Therapy Cooperative Group - North America) held at the Miami Cancer Institute, part of Baptist Health South Florida. 

PTCOG NA crowd

The conference organizers invited Dr. Zeljko Vujaskovic, Director of the Division of Translational Radiation Sciences, University of Maryland School of Medicine, to be a featured speaker at the event.  Dr. Vujaskovic presented "Hyperthermia and Protons: Is This the Safe Way to Get the 'Carbon Effect'?" which included some clinical results from the dual therapy. Dr. Vujaskovic and his team at the UMMC have been treating patients with combined hyperthermia and proton beam since the center opened in 2015. The hospital treats patients with the BSD-500 Superficial/Interstitial and the BSD-2000 Deep Regional Hyperthermia System along with protons with great success. His colleague, Dr. J.D. Snider, presented "Concurrent Pencil Beam Scanning Proton Therapy and Hyperthermia: Growing Experience with Promising Results."

PTCOG NA booth all(L to R) Dr. Gerhard Sennewald, Dr. Sennewald Medizintechnik; Mark Falkowski, CEO and Mark Kidd, VP Sales and Business Development; Pyrexar Medical

Adding hyperthermia to proton therapy is not new. A BSD-2000 Deep Regional Hyperthermia System located at Kantonsspital Aarau, Switzerland, has established protocols for the combined treatment with excellent outcomes. But the hyperthermia suite and the proton center are a 30-minute drive apart.  Therapeutic results can undoubtedly be achieved within the dual therapies recommended target window, but for obvious reasons, this can be a deterrent in best practice and clinical testing. Now with the world's first proton therapy and hyperthermia in the same center (See Hyperthermia + Proton Beam, Now in the US), there are more significant opportunities for clinical research.

There have been a lot of firsts at the Maryland Proton Center. First Proton Center in the region; First center to offer both Hyperthermia + Protons at the same facility, and now they are experiencing another First by treating their 2000th patient!

 

In their press release, the University states that "just three years after opening its doors, the Maryland Proton Treatment Center (MPTC) has reached a major milestone by treating its 2,000th patient. MPTC is the first proton treatment center to open in the District/Maryland/Virginia region. It is also the only treatment center in the world that offers both proton and thermal therapies in one facility". See the complete press release.

A key figure in the success of the thermal oncology department, Dr. Zeljko Vujaskovic, not only advocates for patients under his care; but continues to share his knowledge, research, and advancements in thermal oncology as he travels the globe as a featured speaker at medical conferences. For Pyrexar Medical, it is a privilege to be associated with such a distinguished group of professionals, researchers, and practitioners of thermal oncology.

Take a Virtual Tour of the BSD-2000

Take a virtual visit to the Thermal Oncology department at the University of Maryland and the BSD-2000 Deep Regional Hyperthermia System. [Note: Hold down the mouse key to move the camera, click to move around the room and use the mouse wheel to zoom

Last week we attended the CME accredited educational program offered by the University of Maryland, School of Thermal Oncology held at the Maryland Proton Center.

  • UMMC hyperthermia training
    University of Maryland Thermal Oncology School CME course
    held at the Maryland Proton Center in Baltimore, MD
  • Thermal oncology training team
    The educational team included (left to right) JW Snider, MD; Paul Stauffer;
    Dario Rodrigues, PhD; Jason Molitoris, MD, PhD; Mariana Guerrero,PhD; John Hayes,MD;
    and Zeljko Vujaskovic, MD, Phd
  • Participants from the U.S., Poland, South Korea and key hospitals in the
    U.S. attended the 2-day lecture and workshop
  • Professor Stauffer, from Thomas Jefferson University, discusses Treatment Planning
    and Execution
  • Dr. Rodrigues demonstrates temperature probe placement in a phantom on the BSD-2000
  • BSD-500 Superficial Hyperthermia at University of Maryland
    Dr. Guerrero (UMMC) with Mr. Stauffer (Thomas Jefferson) demonstrate the operation
    of the BSD-500 Superficial/Interstitial Hyperthermia system.
  • Participants discuss the operation of the BSD-2000 Deep Regional Hyperthermia System
  • The thermal oncology staff at the University of Maryland use lasers for
    reliable, repeatable patient positioning
  • Doctors' Biswal and Rodriques discuss operational safety and RF field management
  • Using a phantom to simulate temperature management on the BSD-500
  • South Korean delegation at the Maryland Proton Center

The course drew an international crowd, including physicians from South Korea, Poland, and Japan, as well as prominent cancer centers here in the U.S. From the feedback we received, and this was a five-star educational program, valuable to any member of a thermal oncology team.  Topics covered all aspects of practice management, patient treatment, physics, and workflow. Practice managers shared how adding thermal oncology to their services increased overall service revenue by over 19%.  This information is essential for centers that would like to add hyperthermia systems but require cost justification to receive purchase approval.

Based on the higher than expected turnout and the response from the participants, we hope this to be offered again in 2020.

Pyrexar Medical continues to support educational outreach from organizations like the University of Maryland, Society of Thermal Medicine, European Society for Hyperthermic Oncology, and similar institutions who strive to move forward hyperthermia research in the treatment of cancer. The CME course outline can be found here.

Pyrexar Medical will be an exhibiting sponsor of the PTCOG-NA (Particle Therapy Co-Operative Group - North America) in Miami, Florida, October 14-16, our first participation in this annual event. Pyrexar's interest in proton therapy focused after reading a 2014 article published in the International Journal of Hyperthermia by Prof. Dr. Niloy Datta exploring proton therapy and hyperthermia.

Since then, Pyrexar placed a BSD-2000 Deep Regional Hyperthermia System at the University of Maryland Proton Center.  The first installation in the world to offer both a proton therapy system and hyperthermia system under the same roof.  This installation, along with further clinical study, will move us closer to understanding the relationship of protons combined with focused heating.

For more information on attending the upcoming PTCOG-NA conference, follow the link.

In the last few weeks, Pyrexar products were presented at conferences in Warsaw, Poland; Miami, Florida; Barcelona, Spain; and Münster, Germany.  So thankful for our global partners' efforts to educate oncologists and physicists on the benefits of hyperthermia in the treatment of cancer. We wanted to share a few images of these events with you.

ESHO - Warsaw, Poland

 

Pyrexar ESHO Award

2019 Pyrexar ESHO Award

The ESHO-Pyrexar Award, presented by Dr. Sennewald Medizintechnik Gmbh, is awarded annually for outstanding contributions to hyperthermic oncology, education, and scientific achievement. This year's recipient is Prof. Dr. med. Lars Lindner.  Dr. Lindner is a respected thermal oncologist and researcher, well known for the landmark study "Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma" published in Jama earlier this year.  We congratulate him and his team for their contributions to thermal medicine. More information about ESHO (European Society for Hyperthermic Oncology) can be found here.


SEOR - Barcelona, Spain

Pyrexar at SEOR 2019

Pyrexar's first time at the SEOR (Spanish Society of Radiation Oncology) in Spain, represented by our distributor Magna Medic Systems based in Málaga, Spain.  The organization has been making tremendous strides in the introduction of hyperthermia to oncologists in the region.


DEGRO - Münster, Germany

Pyrexar represented at the DEGRO 2019

Our distribution partner, Dr. Sennewald Medizintechnik Gmb, was a silver sponsor at DEGRO (German Society of Radiation Oncology) and held a lunch symposium focused on reimbursement issues in Germany.


ABS - Miami Florida

Pyrexar Medical exhibiting at the ABS 2019

Pyrexar's first engagement at the ABS (American Brachytherapy Society).  Our goal is to demonstrate that adding hyperthermia as an adjunct to brachytherapy boosted the effectiveness of this radiotherapy treatment without interrupting workflow. It was an excellent show, and we will be back next year.

Magna Medic Systems / Pyrexar Medical at SEOR XX

Pyrexar represented by our distribution partner Magna Medic Systems at the XX Congreso SEOR in Santiago de Compostela, Spain.

Magna Medic Systems / Pyrexar booth at the SEOR Spain

The Sociedad Española de Oncología Clínica (Spanish Society of Radiation Oncology) is an association of more than 1000 specialists from Spain (including doctors in training) whose work is developed primarily in the treatment of cancer through the use of ionizing radiation. The annual meeting is an excellent opportunity to share ideas and data from around the world.

clinica sagrada familia

Earlier this year, Magna Medic placed a BSD-500 Superficial Hyperthermia unit at the Clinica Sagrada Familia in Barcelona, Spain. The facility boasts a 135 bed, 225,000 sqft facility with eight specialty surgical suites to support cardiac surgery, neurosurgery, ophthalmology, general surgery, and traumatology. Clinica Sagrada currently performs over 12,000 surgeries per year.

Logo Magna Medic System
We are very thankful for the hard work the Magna Medic team has done to bring hyperthermia to Spain.