|Tumor||Author||Year||Method||No. of Patients||Title||Journal||Abstract Link|
|Rectal Cancer||Ott||2021||CRT+HT||111||Neoadjuvant Chemoradiation Combined with Regional Hyperthermia in Locally Advanced or Recurrent Rectal Cancer||Cancers|
|Prostate Cancer||Beck||2021||RT+HT||52||Salvage-Radiation Therapy and Regional Hyperthermia for Biochemically Recurrent Prostate Cancer after Radical Prostatectomy||Cancers|
|Rectal Cancer||Gani||2021||RCT+HT||78||Deep regional hyperthermia with preoperative radiochemotherapy in locally advanced rectal cancer, a prospective phase II trial||Radiother Oncol|
|Breast Cancer||Stoetzer||2020||CT+HT||53||Post-Neoadjuvant Gemcitabine and Cisplatin with Regional Hyperthermia for Patients with Triple-Negative Breast Cancer and Non-pCR after Neoadjuvant Chemotherapy: A Single-Institute Experience||Karger|
|MIBC Bladder Cancer||Merten||2019||RCT+HT||369||Long‐Term Experience of Chemoradiotherapy Combined with Deep Regional Hyperthermia for Organ Preservation in High‐Risk Bladder Cancer (Ta, Tis, T1, T2)||The Oncologist|
|Breast Cancer||De-Colle||2019||RT+HT||20||Hyperthermic chest wall re-irradiation in recurrent breast cancer: a prospective observational study||Strahlenther Onkol|
|Anal Cancer||Ott||2018||CRT+HT||112||Chemoradiotherapy with and without deep regional hyperthermia for squamous cell carcinoma of the anus||Strahlenther Onkol|
|Soft Tissue Sarcoma||Issels||2018||CT vs.
|341||Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma: The EORTC 62961-ESHO 95 Randomized Clinical Trial.||JAMA|
|Rectal Cancer||Zwirner||2018||RCT+HT||86||External validation of a rectal cancer outcome prediction model with a cohort of patients treated with preoperative radiochemotherapy and deep regional hyperthermia||IJH|
|Soft Tissue Sarcoma||Angele||2014||CT vs.
|341||Effectiveness of regional hyperthermia with chemotherapy for high-risk retroperitoneal and abdominal soft-tissue sarcoma after complete surgical resection: a subgroup analysis of a randomized phase-III multicenter study.||Ann Surg Oncol|
|Pancreatic Cancer||Tschoep-Lechner||2013||CT+HT||23||Gemcitabine and cisplatin combined with regional hyperthermia as second-line treatment in patients with gemcitabine-refractory advanced pancreatic cancer.||IJH|
|Cervical Cancer||Westermann||2012||RT+HT||68||Long-term survival data of triple modality treatment of stage IIB-III-IVA cervical cancer with the combination of radiotherapy, chemotherapy and hyperthermia - an update.||IJH|
|Rectal Cancer||Schroeder||2012||RCT vs.
|106||Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone.||IJH|
|Cervical Cancer||Heijkoop||2012||RCT+HT||43||Neoadjuvant chemotherapy followed by radiotherapy and concurrent hyperthermia in patients with advanced-stage cervical cancer: a retrospective study||IJH|
|Pancreatic Cancer||Maluta||2011||RCT+HT||68||Regional hyperthermia combined with chemoradiotherapy in primary or recurrent locally advanced pancreatic cancer : an open-label comparative cohort trial||Strahlenther Onkol|
|Ovarian Cancer||Fotopoulou||2010||CT+HT||36||Regional abdominal hyperthermia combined with systemic chemotherapy for the treatment of patients with ovarian cancer relapse: Results of a pilot study||IJH|
|Soft Tissue Sarcoma||Issels||2010||CT vs.
|341||Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study.||Lancet|
|Rectal Cancer||Maluta||2010||RCT+HT||76||Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum||IJH|
|Soft Tissue Sarcoma||Schlemmer||2010||RCT+HT||47||Thermochemotherapy in patients with extremity high-risk soft tissue sarcomas (HR-STS)||IJH|
|Bladder Cancer||Wittlinger||2009||RCT+HT||45||Quadrimodal treatment of high-risk T1 and T2 bladder cancer: transurethral tumor resection followed by concurrent radiochemotherapy and regional deep hyperthermia||Radiother Oncol|
|Cervical Cancer||Franckena||2009||RT vs.
|378||Radiotherapy and hyperthermia for treatment of primary locally advanced cervix cancer: results in 378 patients||IJRO|
|Rectal Cancer||Milani||2008||RCT+RHT||24||Radiochemotherapy in combination with regional hyperthermia in preirradiated patients with recurrent rectal cancer||Strahlenther Onkol|
|Cervical Cancer||Franckena||2008||RT vs.
|114||Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the Dutch Deep Hyperthermia Trial.||IJRO|
|Prostate Cancer||Maluta||2007||CRT+HT||144||Conformal radiotherapy plus local hyperthermia in patients affected by locally advanced high risk prostate cancer: preliminary results of a prospective phase II study||IJH|
|Vaginal Cancer||Aktas||2007||RT+HT||44||Concomitant radiotherapy and hyperthermia for primary carcinoma of the vagina: a cohort study.||Eur J Obstet|
|Cervical Cancer||Sreenivasa||2006||RCT+HT||32||Radiochemotherapy combined with regional pelvic hyperthermia induces high response and resectability rates in patients with nonresectable cervical cancer > or =FIGO IIB "bulky".||IJRO|
|Ovarian Cancer||Jones||2006||CT+HT||41||Intra-peritoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma||IJH|
|Cervical Cancer||Westermann||2005||RCT+HT||68||First results of triple-modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with stage IIB, III, and IVA cervical carcinoma.||Cancer|
|Ovarian Cancer||Hahn||2005||CT+HT||32||Prospective assessment of quality of life in ovarian cancer patients receiving whole abdomen hyperthermia and liposomal doxorubicin.||IJH|
|Ovarian Cancer||Alvarez Secord||2005||CT+HT||30||Phase I/II trial of intravenous Doxil and whole abdomen hyperthermia in patients with refractory ovarian cancer.||IJH|
|Prostrate Cancer||Tilly||2005||RT+HT||22||Regional hyperthermia in conjunction with definitive radiotherapy against recurrent or locally advanced prostate cancer T3 pN0 M0.||Strahlenther Onkol|
|Technical Study||Gellermann||2005||MRI Imaging||Methods and potentials of magnetic resonance imaging for monitoring radiofrequency hyperthermia in a hybrid system||IJH|
|Rectal Cancer||Hildebrandt||2004||RT+HT||9||Regional pelvic hyperthermia as an adjunct to chemotherapy (oxaliplatin, folinic acid, 5-fluorouracil) in pre-irradiated patients with locally recurrent rectal cancer: a pilot study.||IJH|
|Soft Tissue Sarcoma||Fiegl||2004||CT+HT||20||Ifosfamide, carboplatin and etoposide (ICE) as second-line regimen alone and in combination with regional hyperthermia is active in chemo-pre-treated advanced soft tissue sarcoma of adults.||IJH|
|Rectal Cancer||Juffermans||2003||RT+HT||54||Reirradiation and hyperthermia in rectal carcinoma: a retrospective study on palliative effect.||Cancer|
|Cervical Cancer||Jones||2003||RT+HT||12||A pilot Phase II trial of concurrent radiotherapy, chemotherapy, and hyperthermia for locally advanced cervical carcinoma.||Cancer|
|Prostate Cancer||Kalapurakal||2003||RT+HT||13||Efficacy of irradiation and external hyperthermia in locally advanced, hormone-refractory or radiation recurrent prostate cancer: a preliminary report.||IJRO|
|Cervical Cancer||Van der Zee||2003||RT vs.
|114||The Dutch Deep Hyperthermia Trial: results in cervical cancer||IJH|
|Rectal Cancer||Romano||2003||RT+HT||57||Pre-operative radio-chemotherapy plus regional hyperthermia in the treatment of advanced rectal cancer: experience with radiation dose escalation||IJRO|
|Pediatric Tumors||Wesslowski||2003||CT+HT||39||An approach for cure: PEI-chemotherapy and regional deep hyperthermia in children and adolescents with unresectable malignant tumors||Klin Padiatr|
|Soft Tissue Sarcoma||Wendtner||2002||CT+HT||58||Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas.||JCO|
|Soft Tissue Sarcoma||Issels||2001||CT+HT||59||Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults: long-term results of a phase II study.||Eur J Cancer|
|Germ Cell Tumors||Schneider||2001||CT+HT||22||Treatment of recurrent malignant sacrococcygeal germ cell tumors: analysis of 22 patients registered in the German protocols MAKEI 83/86, 89, and 96.||JCO|
|Soft Tissue Sarcoma||Wendtner||2001||RCT+HT||54||Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia.||Eur J Cancer|
|Technical Study||Maguire||2001||Thermal Dose||A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy||IJH|
|Prostate Cancer||Kalapurakal||2001||RT+HT||3||Re-irradiation and external hyperthermia in locally advanced, radiation recurrent, hormone refractory prostate cancer: a preliminary report.||Br J Radiol|
|Technical Study||Tilly||2001||Specific Absorbtion Rate||Temperature data and specific absorption rates in pelvic tumours: predictive factors and correlations.||IJH|
|Rectal Cancer||Anscher||2000||CT+HT||15||A pilot study of preoperative continuous infusion 5-fluorouracil, external microwave hyperthermia, and external beam radiotherapy for treatment of locally advanced, unresectable, or recurrent rectal cancer.||IJRO|
|Cervical Cancer||Van der Zee||2000||RT vs.
|114||Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group||Lancet|
|Rectal Cancer||Rau||2000||RCT+HT||54||Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters.||IJRO|
|Bladder Cancer||Van der Zee||2000||MMC+RT vs.
|101||Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group||Lancet|
|Rectal Cancer||Van der Zee||2000||RT vs.
|143||Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group||Lancet|
|Soft Tissue Sarcoma||Prosnitz||1999||RT+HT||97||The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy.||IJRO|
|Cervical Cancer||de Wit||1999||CT+HT||19||A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix.||Br J Radiol|
|Germ Cell Tumor||Wessalowski||1998||CT+HT||7||Hyperthermia for the treatment of patients with malignant germ cell tumors: a phase I/II study in ten children and adolescents with recurrent or refractory tumors||Cancer|
|Rectal Cancer||Rau||1998||RCT+HT||37||Preoperative hyperthermia combined with radiochemotherapy in locally advanced rectal cancer: a phase II clinical trial.||Ann Surg Oncol|
|Germ Cell Tumor||Wessalowski||1997||CT+HT||9||Treatment results in children and adolescents with loco-regional recurrences of abdominal germ cell tumors (GCTs): a pilot-study with PEI chemotherapy and regional deep hyperthermia (RHT) in comparison to a matched cohort||Klin Padiatr|
|Prostate||Anscher||1997||RT+HT||30||Combined external beam irradiation and external regional hyperthermia for locally advanced adenocarcinoma of the prostate.||IJRO|
|Deep Tumors||Myerson||1996||RT+HT||66||A phase I/II study to evaluate radiation therapy and hyperthermia for deep-seated tumours: a report of RTOG 89-08.||IJH|
|Soft Tissue Sarcoma||Scully||1994||RT+HT||40||Clinical outcome after neoadjuvant thermoradiotherapy in high grade soft tissue sarcomas||J Surg Oncol|
|Head & Neck Cancer||Valdagni||1994||RT vs.
|44||Radical radiation alone versus radical radiation plus microwave hyperthermia for N3 (TNM-UICC) neck nodes: a prospective randomized clinical trial.||IJRO|
|Technical Study||Feldmann||1993||Temperature||Deep regional hyperthermia: comparison between the annular phased array and the sigma-60 applicator in the same patients.||IJRO|
|Prostate||Kaplan||1991||RT+HT||6||Secondary external-beam radiotherapy and hyperthermia for local recurrence after 125-iodine implantation in adenocarcinoma of the prostate||IJRO|
|Genitourinary Cancer||1991||RT vs.
|53||Regional hyperthermia in patients with recurrent genitourinary cancer.||Am J Clin Oncol|
|Technical Study||Myerson||1991||Phantom||Phantom studies and preliminary clinical experience with the BSD 2000||IJH|
|Soft Tissue Sarcoma||Issels||1990||CT+HT||40||Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally advanced sarcomas: a phase II study.||JCO|
RT-Radiotherapy; HT-Hyperthermia; LHT-Local Hyperthermia; CHT-Chemothyperthermia; CTX-Chemotherapy; MMC-Mitomycin C; EHT; Endocavity Hyperthermia; IHT-Interstitial Hyperthermia; HIPEC-Heated Intraperitoneal Chemotherapy; RCT-RadioChemotherapy; BCG-Bacillus Calmette-Guerin; CRT-Conformal Radiotherapy