BSD Medical is Now Pyrexar Medical

The complete line of BSD Hyperthermia products are availble thru Pyrexar Medical

Wall Street Journal Article

The Wall Street Journal just published an article on Hyperthermia’s resurgence in the medical scene. Although the article lacks to mention some of the amazing results that this therapy produces in cervical, bladder, pancreatic, melanoma, ovarian, breast, esophageal, prostate and head/neck cancers (to name a few), it at minimum brings hyperthermia back in the spot light.  READ THE ARTICLE

The article mentions some studies in the 90’s where outcomes were not as stellar as they are today. This may be due to early lab built equipment and poor protocols had much to do with that data. Today, with our BSD-500 Superficial/Interstitial and BSD-2000 Deep Regional systems at the center of many important phase III medical trials, results can be 2 to 3 times greater when adding hyperthermia to chemotherapy and radiotherapy.

Immunology is the real story here. The body is a wonderful cancer fighting device. Heating the cancerous tumors to fever temperatures (42-42˚C) appears to unmask cancer from the bodies immune system. We will see results of this ongoing research and study of the immunological effect in the near future.

Resources: Fever and the thermal regulation of immunity: the immune system feels the heat; Sharon S. Evans,Elizabeth A. Repasky& Daniel T. Fisher

rsna outdoor flag

This year the Radiological Society of North America (RSNA) held in Chicago attracted an estimated 55,0000 medical professionals from around the world.  Wandering through the maze of displays by medical device manufacturers were an army of international distributors looking for something new.

“Something new” seemed to be the theme of the five day event and hyperthermia seemed to fit the bill.  The show provided a personal introduction and interaction platform that no brochure, website or email can reproduce.  Key players from Europe, Asia, South America and the Middle East passed through the booth to learn about the amazing benefits that hyperthermia had to offer.

In addition to the wealth of business opportunities, medical and technical students had the opportunity to see and touch the equipment with which they may one day participate. As the only representative company for this particular therapy at the show, we felt great privilege in participating in the educational process.

Overall the show was a great success.  Some incredible business relationships were formed and some big deals solidified. But you will need to wait a bit before we can reveal that news.

RSNA15 mapThis year the Radiological Society of North America (RSNA) will hold its annual meeting in Chicago marking the organization's 100th anniversary.  The RSNA is the world's largest annual medical meeting with attendance estimated at 55,000 people.  The five day event includes two large exhibition halls presenting medical device products and a full schedule of presentations and education.  The program starts Sunday, Nov 29th and runs thru Thursday Dec. 3rd.

Since this is a really big show, I have included a map Link to help you find us. Our booth, #6563, is located in the far end of North Building, Hall B, just past the end of the Philips booth and directly across from North Cafe.

In addition to our booth and sales team, you may be interested in a lecture by Mark Dewhirst, DVM, PhD from Duke University Medical Center. "Lessons Learned from XRT/Hyperthermia | VISIO41-03” will discuss how hyperthermia compliments the ability of radiotherapy to kill cancer cells include a review of the more than a dozen positive phase III cancer trials; and provide new insights on how hyperthermia affects the process of DNA damage repair.

Lessons Learned from XRT/Hyperthermia
    Wednesday 1:55-2:10 PM | VSIO41-03 | S405AB

Mark W. Dewhirst, DVM, PhD durham, NC (Presenter)
Stockholder, Celsion Corporation Research Grant, Biomimetix Corporation Research Grant, Johnson & Johnson Consultant, Nevro Corp Consultant, Merck KGaA Consultant, Siva Corporation

1) Understand the complimentary interactions between hyperthermia and radiotherapy that increase cell killing. 2) Understand importance of measuring temperature during heating and methods for how this is accomplished. 3) Be able to articulate how hyperthermia affects tumor physiology and how these effects influence treatment responses.

There are more than a dozen positive phase III trials showing that hyperthermia can increase local tumor control when it is combined with radiotherapy. Such trials include head and neck cancer, cervix cancer, GBM, esophageal cancer and chest wall recurrences of breast cancer. It has been known for more than two decades that hyperthermia augments the cytotoxicity of radiotherapy. Basic tenants underlying this interaction include proof that hyperthermia inhibits DNA damage-repair. Hyperthermia has complimentary cytotoxicity with radiotherapy in different parts of the cell cycle. Further, hyperthermia can increase tumor perfusion, thereby increasing oxygen delivery; lack of oxygen is a source of relative resistance to radiotherapy. In recent years, however, new insights have been made into how these two treatment modalities interact. These insights come from: 1) innovative clinical trials involving functional imaging and genomics and 2) examination of how hyperthermia affects the process of DNA damage repair. These developments point the way toward new methods to further therapeutic gain by taking advantage of cellular responses to these therapies.

Hadron Therapy Workshop

This year’s “Workshop on Hadron Therapy” was hosted by the Mesoamerican Center for Theoretical Physics (MCTP) and FIMENUTEP (Nuclear and Medical Physics Proton Therapy) in Tuxtla Gutierrez in the state of Chiapas, Mexico.  The three-day summit brought together experts from around the world to discuss the benefits and implementation of proton therapy in the treatment of cancer.  Presenters included the Mayo Clinic, University Hospital of Geneva, John Hopkins School of Medicine and Benemérita Universidad Autónoma de Puebla (BUAP).

Mark Falkowski, CEO at Pyrexar Medical, was invited as the industry leader in thermal therapy medical devices to present the topic “Hyperthermia for Proton Therapy”.  Interest in the combined therapy was piqued by a paper published in 2014 by N. Datta entitled, “Could hyperthermia with proton therapy mimic carbon ion therapy?”  This research is important as it postulates that not only could adding hyperthermia to proton therapy increase the effectiveness, but also potentially mimic the superior results of carbon ion therapy without the magnitude higher systems cost.

Currently, there is a multi-institutional phase I/II clinical trial with concomitant local hyperthermia and proton beam radiotherapy at the Kantonsspital Aarau in Switzerland. Hyperthermia is a well-known sensitizer of cancer tumors, increasing tumor response and increasing effective dose in radiation therapy.  Researchers have measured increases in tumor control and complete response in many cancers when adding hyperthermia to chemotherapy and traditional radiotherapy. The new study is designed to measure the effective downstaging of soft tissue sarcoma tumors when adding hyperthermia to proton therapy.
The Hadron Therapy Workshop provided another opportunity to share the hyperthermia message with medical experts, staff and university researchers focused on increasing the effectiveness of cancer treatments. Pyrexar Medical continues to ask the question, “If there is a pain-free, harm-free way to increase cancer survival rates, why not choose to use it?”