BSD Medical is Now Pyrexar Medical

The complete line of BSD Hyperthermia products are availble thru Pyrexar Medical

The First Affiliated Hospital of Zhengzhou University celebrated the opening of its thermal oncology center located in the Henan province of mainland China.  The hospital constructed a custom hyperthermia suite to house the BSD-2000 Deep Regional Hyperthermia system built by Pyrexar Medical.  First Affiliated has a long history of hyperthermic clinical research and plans to further pioneer its use, in addition to general clinical use for their cancer patients.

Often referred to as "the largest hospital in the world", First Affiliated offers 7,000 beds. Compare that to the largest medical center in the US, New York-Presbyterian at 2,678 and you get to understand the colossal scale of the facility.

  • BSD-2000 Deep Regional Hyperthermia

The opening celebration included a presentation ceremony, lectures on hyperthermia in the treatment of cancer, and a tour of the facility, attracting physicians and medical professionals from the area.

What does that mean for the future of hyperthermia in China? Thermal therapy has long been accepted in Asia and is growing steadily. The prestige,  influence, and access of a medical facility of this magnitude is expected to result in accelerated demand for Pyrexar system installations throughout China.

A special thanks to the talented team at our distributor Dalian Orientech for their dedication to bringing the best in medical technology to the region.

Soft Tissue Sarcoma cancer study using hyperthermia

The link between increased longevity and hyperthermia treatment was considered a landmark study when it published in late 2018 in the Journal of the American Medical Association.

sennewald sts infographic

Recently, our partners at Sennewald Medizintechnik, caught up with renowned expert and cancer study co-author Professor Dr. Lars Lindner of Ludwig-Maximilians-Universität (LMU) in Munich to get a deeper understanding of the findings.

After examining over 30 Soft Tissue Sarcoma trials, Prof. Dr. Linder lists the top four significant findings:

  1. Doxorubicin-based chemotherapy is and remains the standard of care for soft tissue sarcomas.
  2. The benefit of chemotherapy has also been shown in the adjuvant situation in high-risk patients.
  3. Neoadjuvant therapy is preferable because it combats potential micrometastasis at the earliest possible time and improves operability.
  4. Regional hyperthermia improves the effectiveness of chemotherapy and leads to improved patient survival.

The complete interview is available on the Sennewald Medizintechnik April 2021 newsletter.

ESHO-Pyrexar Award Winner Dr. Niloy Datta

The 2020 ESHO-Pyrexar Award presentation included the history and merits of Professor Niloy Datta, celebrating his achievements in the field of thermal oncology.  What follows the award presentation is nothing less than a Master Class in thermal oncology.  Dr. Datta shares highlights of his research and his vision for the pathway to hyperthermia expansion and success.

esho datta 2

Along with presenting evidence of the increased value to the patient that hyperthermia brings, Dr. Datta also touches on the financial rationale of adding a thermal oncology program to your hospital.

esho datta 3

Below find a summary of recently published works involving hyperthermia by Datta et al.

Concurrent chemoradiotherapy vs. radiotherapy alone in locally advanced cervix cancer: A systematic review and meta-analysis.
Datta NR, Stutz E, Liu M, Rogers S, Klingbiel D, Siebenhüner A, Singh S, Bodis S.
Gynecol Oncol. 2017 May;145(2):374-385. doi: 10.1016/j.ygyno.2017.01.033. Epub 2017 Feb 7.
PMID: 28188016 Review.
Integrating Loco-Regional Hyperthermia Into the Current Oncology Practice: SWOT and TOWS Analyses.
Datta NR, Kok HP, Crezee H, Gaipl US, Bodis S.
Front Oncol. 2020 Jun 12;10:819. doi: 10.3389/fonc.2020.00819. eCollection 2020.
PMID: 32596144 Free PMC article. Review.
Hyperthermia and radiotherapy in bladder cancer.
Snider JW 3rd, Datta NR, Vujaskovic Z.
Int J Hyperthermia. 2016 Jun;32(4):398-406. doi: 10.3109/02656736.2016.1150524. Epub 2016 Apr 20.
PMID: 27097528 Review.
Hyperthermia with radiotherapy reduces tumour alpha/beta: Insights from trials of thermoradiotherapy vs. radiotherapy alone.
Datta NR, Bodis S.
Radiother Oncol. 2019 Sep;138:1-8. doi: 10.1016/j.radonc.2019.05.002. Epub 2019 May 24.
PMID: 31132683
Hyperthermia with photon radiotherapy is thermoradiobiologically analogous to neutrons for tumors without enhanced normal tissue toxicity.
Datta NR, Bodis S.
Int J Hyperthermia. 2019;36(1):1073-1078. doi: 10.1080/02656736.2019.1679895.
PMID: 31709846
Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas.
Tran S, Puric E, Walser M, Poel R, Datta NR, Heuberger J, Pica A, Marder D, Lomax N, Bolsi A, Morach P, Bachtiary B, Seddon BM, Schneider R, Bodis S, Weber DC.
Br J Radiol. 2020 Mar;93(1107):20180883. doi: 10.1259/bjr.20180883. Epub 2019 May 14.
PMID: 30943055
A Pilot Study of Radiotherapy and Local Hyperthermia in Elderly Patients With Muscle-Invasive Bladder Cancers Unfit for Definitive Surgery or Chemoradiotherapy.
Datta NR, Stutz E, Puric E, Eberle B, Meister A, Marder D, Timm O, Rogers S, Wyler S, Bodis S.
Front Oncol. 2019 Sep 10;9:889. doi: 10.3389/fonc.2019.00889. eCollection 2019.
PMID: 31552192 Free PMC article.
Local hyperthermia combined with radiotherapy and-/or chemotherapy: recent advances and promises for the future.
Datta NR, Ordóñez SG, Gaipl US, Paulides MM, Crezee H, Gellermann J, Marder D, Puric E, Bodis S.
Cancer Treat Rev. 2015 Nov;41(9):742-53. doi: 10.1016/j.ctrv.2015.05.009. Epub 2015 May 27.
PMID: 26051911 Review.
Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis.
Datta NR, Rogers S, Ordóñez SG, Puric E, Bodis S.
Int J Hyperthermia. 2016;32(1):31-40. doi: 10.3109/02656736.2015.1099746. Epub 2015 Nov 16.
PMID: 26928474 Review.
Hyperthermia and Radiation Therapy in Locoregional Recurrent Breast Cancers: A Systematic Review and Meta-analysis.
Datta NR, Puric E, Klingbiel D, Gomez S, Bodis S.
Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1073-87. doi: 10.1016/j.ijrobp.2015.12.361. Epub 2015 Dec 21.
PMID: 26899950 Review.
Hyperthermia and radiotherapy with or without chemotherapy in locally advanced cervical cancer: a systematic review with conventional and network meta-analyses.
Datta NR, Rogers S, Klingbiel D, Gómez S, Puric E, Bodis S.
Int J Hyperthermia. 2016 Nov;32(7):809-21. doi: 10.1080/02656736.2016.1195924. Epub 2016 Aug 14.
PMID: 27411568 Review.
Proton Irradiation with Hyperthermia in Unresectable Soft Tissue Sarcoma.
Datta NR, Schneider R, Puric E, Ahlhelm FJ, Marder D, Bodis S, Weber DC.
Int J Part Ther. 2016 Fall;3(2):327-336. doi: 10.14338/IJPT-16-00016.1. Epub 2016 Dec 30.
PMID: 31772984 Free PMC article.
Could hyperthermia with proton therapy mimic carbon ion therapy? Exploring a thermo-radiobiological rationale.
Datta NR, Puric E, Schneider R, Weber DC, Rogers S, Bodis S.
Int J Hyperthermia. 2014 Nov;30(7):524-30. doi: 10.3109/02656736.2014.963703. Epub 2014 Oct 14.
PMID: 25314095
Hyperthermia and reirradiation for locoregional recurrences in preirradiated breast cancers: a single institutional experience.
Datta NR, Puric E, Heüberger J, Marder D, Lomax N, Timm O, Memminger P, Bodis S.
Swiss Med Wkly. 2015 Apr 23;145:w14133. doi: 10.4414/smw.2015.14133. eCollection 2015.
PMID: 25906357
"HEATPAC" - a phase II randomized study of concurrent thermochemoradiotherapy versus chemoradiotherapy alone in locally advanced pancreatic cancer.
Datta NR, Pestalozzi B, Clavien PA, Siebenhüner A, Puric E, Khan S, Mamot C, Riesterer O, Knuchel J, Reiner CS, Bodis S; members of the HEATPAC Trial Group.
Radiat Oncol. 2017 Nov 21;12(1):183. doi: 10.1186/s13014-017-0923-8.
PMID: 29162142 Free PMC article. Clinical Trial.
Enhanced tumour regression in a patient of liposarcoma treated with radiotherapy and hyperthermia: Hint for dynamic immunomodulation by hyperthermia.
Datta NR, Grobholz R, Puric E, Bode-Lesniewska B, Lomax N, Khan S, Gaipl US, Fuchs B, Bodis S.
Int J Hyperthermia. 2015;31(5):574-7. doi: 10.3109/02656736.2015.1033482. Epub 2015 Apr 20.
PMID: 25893831 No abstract available.

 A special thanks to Dr. Sennewald Medizintechnik for sponsoring the award and presentation.

Medical news may be dominated by pandemic coverage, but cancer research still moves forward.  We did a quick search on for trials using hyperthermia as an adjunct to radiotherapy, chemotherapy, and immunotherapy.  The listing below is a summary of studies around the world. 

Clinical Study Indication Facility Country  Pyrexar Installation
Hyperthermia and High Dose Rate Radiation Therapy in Treating Patients With Recurrent Prostate Cancer After Radiation Prostate Cancer Sidney Kimmel Cancer Center at Thomas Jefferson University USA ✔ 
Hyperthermia and Proton Therapy in Unresectable Soft Tissue Sarcoma Soft Tissue Sarcoma Kantonsspital Aarau Switzerland
Effectiveness of the Combined WLI and Hyperthermia for GI Cancer Liver Metastasis Metastatic Liver Cancer Samsung Medical Center South Korea  
Hypofractionated Radiotherapy With Hyperthermia in Unresectable or Marginally Resectable Soft Tissue Sarcomas Soft Tissue Sarcoma Maria Sklodowska-Curie Institute - Oncology Center Poland  
Combination of Hyperthermia and Concurrent Chemoradiotherapy (CCRT) for Recurrent Head and Neck Cancer Head/Neck Shin Kong Wu Ho-Su Memorial Hospital Taiwan  
Radiotherapy With Hyperthermia in Recurrent and Radiation-Induced Sarcomas Sarcoma Maria Sklodowska-Curie National Research Institute of Oncology  Poland  
Preoperative Radiochemotherapy With Hyperthermia for Locally Advanced Rectal Cancer Rectal Cancer University Hospital Tübingen Germany  
Salvage Brachytherapy and Hyperthermia for Recurrent H&N-tumours Head/Neck Cancer Sidney Kimmel Cancer Center at Thomas Jefferson University  United States  
Local Hyperthermia for the Treatment of Cervical Intraepithelial Neoplasias Cervical Cancer First Hospital of China Medical University China  
Image-guided Targeted Doxorubicin Delivery With Hyperthermia to Optimize Loco-regional Control in Breast Cancer Breast Cancer University Medical Center Utrecht Netherlands  
Hyperthermia European Adjuvant Trial Pancreatic Cancer Klinikum Grosshadern Medical Center Germany
Salvage Brachytherapy and Interstitial Hyperthermia for Locally Recurrent Prostate Carcinoma Following Radiation Therapy

Prostate Cancer
Strahlenklinik im Universitaetsklinikum Erlangen Germany

 Centrum Radiotherapy  Poland  
 Maria Sklodowska-Curie Institute - Oncology Center  Poland  
Effects of Deep Regional Hyperthermia in Patients With Anal Carcinoma Treated by Standard Radiochemotherapy Anal Cancer Universitaetsklinikum Erlangen Germany  
Concurrent Hyperthermia and Chemoradiotherapy in LAPC: Phase II Study Pancreatic Cancer Kantonsspital Aarau Switzerland  
Neoadjuvant Chemoradiation With 5-FU(or Capecitabine) and Oxaliplatin Combined With Hyperthermia in Rectal Cancer

Rectal Cancer   Klinik Bad Trissl  Germany   
Bad Trissl  Germany  
 University Hospital Duesseldorf  Germany  
 Universitätsklinikum Erlangen  Germany  
Radiation Therapy or Chemoradiation Interstitial Brachytherapy in Combination With Hyperthermia in Advanced Cervical Cancer Cervical Cancer Universitätsklinikum Erlangen Germany  
Combination of Immunotherapy and Hyperthermia in Advanced Malignant Mesothelioma Mesothelioma Capital Medical University Cancer Center China  
Regional hyperthermia and salvage radiotherapy is being tested in patients with biochemically recurrent prostate cancer after radical prostatectomy Prostate Cancer Universitätsklinikum Tübingen  Germany  
Universitätsklinikum Erlangen  Germany  
Charité Universitätsmedizin Germany  
Organ Preservation in Locally Advanced Rectal Cancer by Radiochemotherapy Followed by Consolidation Chemotherapy    Rectal Cancer    University Hospital Erlangen   Germany  
University Hospital Frankfurt  Germany  
University Hospital Tübingen Germany  
University Hospital Würzburg Germany  

HIPEC studies have not been included in this list. Listing facilities with Pyrexar hyperthermia systems is not a statement that those systems are used in the study, only that they exist at the facilities conducting the study.  If you know of a study not included in the list, please let us know, and we would be happy to share it on our website.