BSD Medical is Now Pyrexar Medical

The complete line of BSD Hyperthermia products are availble thru Pyrexar Medical

Society of Thermal Medicine (STM) Annual conference held at the Westin La Paloma Resort in Tucson Arizona. Average daily temperature was 100˚F

Pyrexar displayed some new applicators for the BSD-2000 3D/MR, as well as an upgrade (touch monitor / software / temperature box) for the BSD-2000 family

The Sigma 30/MR is a MR compatible applicator for treating limbs and pediatric patients. The new design fits into the MRI table tray and can shift left and right for patient comfort. Like the Sigma Eye/MR it is removable allowing for general imaging use.

Martin Wadepohl of Senewald Medizintechnik presented "MR Thermometry: New Scanners - New Challenges" at the Modeling, Monitoring, Measuring and Computation section

(L to R) James Snider, MD, Jason Molitoris, MD, PhD, Emily Kowalski, MD, Jill Remick. MD, Zeljko Vujaskovic, MD. PhD - University of Maryland's radiation oncology group was in full force at the STM. Great presentations on hyperthermia!

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  • STM (Society of Thermal Medicine) Conference in Tucson, AZ
  • Over 100 presentations on thermal technologies and research
  • Hyperthermia = New business - Discover how hyperthermia increases the bottom line
  • New Pyrexar Applicators on display
  • Did I mention it was 103˚F in May

We just returned from a week-long STM conference in Tucson, Arizona (May 7-10, 2018). The theme of the meeting was "Temperature Matters". The thermometer reached 103˚F with a relative humidity of 5%... and "YES" it mattered!

There were over 100 presentations on thermal effect, including radiative hyperthermia, MR-guided thermal therapy, nano particles, HIFU, HIPEC, laser interstitial thermal therapy, immunology, cryotherapy and radio-biology. The common thread among all hyperthermia applications is that it is a valuable therapy in the treatment of cancer. But without financial rational and support, none of these technologies will reach the patient.

Hyperthermia = New business

We all care about results, but reimbursement is what gives you the ability to continue treating patients. That is why we wanted to highlight one presentation that stood out in our mind - "The Impact of Hyperthermia Therapy on Patient Referrals and Patterns of Care within a Radiation Oncology Department" by Dr. J. Remek from the University of Maryland Department of Radiation. In summary, actual reimbursement for a single hyperthermia treatment was less important than the additional services that a hyperthermia patient brings to the practice. Dr. Remek tallied all of the billable services rendered at the University of Maryland associated with its BSD-500 Superficial/Interstitial Hyperthermia System in the radiation oncology department (U of M is installing a BSD-2000 in their Proton Center). Of their sampling of patients who received hyperthermia, the additional radiation, imaging and care services increased their revenue stream by 15%-19%. Their reasoning is that new patients, referred from outside the hospitals network, increase billable services that they would not have received if they did not offer hyperthermia.

The STM conference is a intimate show, with 150-200 participants. Pyrexar sponsors the show, not to find customers, but as an effort to support hyperthermia research and the STM organization. We still like to show off what we have been up to and our small 10ft booth was packed with lots of new stuff.

STM booth numbered

  1. Our backdrop is an image of the new BSD-2000 3D/MR installed in Grosshardern University Hospital, Munich, Germany. It represents a significant advancement in Image Guided Thermal Therapy.  [Currently available in select EU countries]

  2. Elevated on a stand on the left is the Sigma Eye/MR applicator, (internally we call the Universal). The Universal code name represent the ability to quickly deploy our applicator onto any MR table with a form factor that will fit most, newer MRI systems. Previously, we would build a custom gantry for each MR model requiring significant engineering and time. Now hyperthermia can be provided in the active MRI, then removed quickly for traditional imaging. [Currently available in select EU countries]

  3. On the table to the left is the brand new Sigma 30/MR applicator. This applicator is often used to treat Soft Tissue Sarcoma of the limbs. Just in time for the JAMA release of the long term STS phase III clinical study recently published in JAMA. The 30cm bore applicator has also been used in pediatric cases of germ cell tumors. [Currently available in select EU countries]

  4. Next on the table is a new innovation for existing BSD-2000 users. We have a new large screen touch monitor and upgraded control software. The software has the same ability to monitor and control the heat zone, but the user interface has been formatted to more user-friendly.

  5. In front of the screen is the new temperature box. Repackaged to be user-friendly and less obtrusive, the temperature box features improved probe connectors and a probe calibration well similar to the BSD-500. Instead of a water bath, the user inserts the end of the probe into the well and initiates calibration. Quick and easy.

Last but not least..... Sorry we can not talk about the last item. We are currently in development of a new device. If you attend the ESHO show this week, you may get a closer look.

We had the honor to introduce Pyrexar Medical's line of hyperthermia equipment and present the benefits of hyperthermia in the treatment of cancer, to a VIP delegation from Vietnam last week.  The presentation was held in Portland, Oregon while the group was in the US to investigate the latest medical device technologies.  Participants included the Vice President and Vice Chairman of Ủy ban nhân dân thành phố Hà Nội representing the Peoples's Committee of the Hanoi Government and representatives from VinMec International Hospital, and Hanoi High Tech and Digestive Center at St. Paul's Hospital in Hanoi.

Vietnam has one of south-east Asia's fastest-growing economies and continues to improve and expand its medical services to care for its citizens. With a population of 93 million, cancer treatment is a priority. The top five most frequent new cancers cases in Vietnam are the liver (17.6 %s), lung (17.5 %), stomach (11.4%), breast (8.9%) and colorectum (7% ) .  As hyperthermia re-emerges as a viable therapy, especially with data supporting immune response, the country's medical community is taking notice.

Pyrexar is currently in final negotiations with Dang Tran Dung, CEO of Thai Thinh Medicine, to represent our line of superficial and deep regional hyperthermia products in Vietnam. We hope to start the regulatory process with the Ministry of Health within the next 90 days.

Pyrexar traveled to Kuwait to address physicians at the Kuwait Cancer Control Center (KCCC). Founded in 1968, the KCCC is affiliated with the Kuwait Ministry of Health and is dedicated to provide Cancer Care across the State of Kuwait. The center utilizes all available resources to serve cancer patients with a wide selection of treatment modalities. We hope to see hyperthermia as a featured treatment option this year.

Ahmed El Ghamry, Business Unit Manager, MedVision | Mark Falkowski, CEO - Pyrexar Medical | Ali Rabie, Senior Product Specialist, MedVision at the GUG Exhibit

International Conference on Genitourinary & Gynecological Cancers - Kuwait Conference April 14-16

Salwa Sabah Al-Ahmad presentation hall at the Marina Hotel

Salwa Sabah Al-Ahmad Theater & Hall in Kuwait City

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While there, we joined our Middle East distribution partner Medvision at their booth at the GUG-KC (Genitourinary & Gyneclogical Cancers Kuwait Conference) held at the Salwa Sabah Al-Ahmad Theatre. The booth was visited by Dr. Mustafa Redah, Co-Minister of Health; Dr. Kholoud Al Ali, head of the KCCC; and Dr. Al Saleh, head of Radiation Oncology at KCCC. The group was very impressed by the new technologies Pyrexar has pioneered and the benefits of hyperthermia in the treatment of cancer.

A special thanks to the Medvision team for their generous hospitality during the event.

I wanted to share this recent communication from our colleagues at Sennewald Medizintechnik.


There are only a few weeks to go until the ESHO Meeting in Berlin and it is not too late to register via ESHO Congress website, if you have not already done so. We asked Dr. Pirus Ghadjar (ESHO 2018 Congress Organization) to outline the main highlights of the event.

Since the hyperthermia department at the Charité Universitätsmedizin in Berlin is one of the nine centers that contributed to the long-term results of the EORTC 62961-ESHO 95 trial recently published in JAMA Oncology Journal, we also asked Dr. Ghadjar some

more detailed questions about the trial. You will find his answers below.The hyperthermia systems used in the trial were provided by BSD/Pyrexar Medical, so we are pleased to point out that as a Diamond Sponsor of the ESHO Meeting, we are holding a Lunch Symposium on May 17 on “Pyrexar Innovations 2018”.

DR. GHADJAR  ABOUT -  ESHO 2018

Ghadjar.297x337JPGDr. Ghadjar, could you please summarize the highlights of the ESHO 2018 program?
I am pleased to say that the program of this year’s ESHO is very interesting and includes several highlights. For instance, the "abdominal tumor" session providing information on the latest treatment for pancreatic cancer and liver tumors and the use of hyperthermia to improve current treatment standards for abdominal tumors. The session on "MR-guided thermal therapies and applications" will summarize recent developments in MR thermometry as well as MR-based heat treatments. Another highlight -- among others -- will be the session on "Immune effects of hyperthermia and novel drug combinations" where the combination of hyperthermia and checkpoint inhibitors will be discussed.

The 2018 ESHO program also includes a one-day nurse/radiation therapist symposium, as well as a Patient Information Day, which will be held in German.

INTERVIEW DR. GHADJAR JAMA ONCOLOGY JOURNAL PUBLICATION

1. The EORTC 62961-ESHO 95 Trial was completed in November 2006. Why is JAMA Oncology only reporting now and what is the significance?

Long term data of the EORTC 62961-ESHO 95 trial comparing neoadjuvant chemotherapy vs. neoadjuvant regional hyperthermia plus chemotherapy for patients with localized high-risk soft tissue sarcoma was published by Issels et al. in February 2018 based on a median follow-up of 11.3 years. The recruitment of the total number of 341 patients was conducted from July 1997 to November 2006. The database for this analysis was closed in December 2014. The long follow-up duration is necessary to analyze potential differences in the secondary trial endpoint of overall survival. The significance of the results is that the addition of regional hyperthermia did not only improve local progression-free survival but also significantly improved overall survival as compared to neoadjuvant chemotherapy alone.

2. But why has it taken so long to publish the results?

Issels et al. closely analyzed their data after the database was closed. Due to the unique and convincing data, the manuscript was then submitted to high-impact medical journals and the process of manuscript review, re-submission and revision took time until the manuscript was accepted for publication by JAMA Oncology.

3. Is it true the study was prematurely halted? Were there negative results?

No, the predefined analysis plan as stated in the trial protocol was followed. The early trial results were published in Lancet Oncology in 2010, reporting that the primary trial endpoint local progression-free survival was significantly improved by neoadjuvant regional hyperthermia plus chemotherapy vs. neoadjuvant chemotherapy alone based on a median follow-up of 34 months. As the primary trial endpoint was significantly improved (as far back as 2010) the trial had to be regarded as a positive one. In 2010 the follow-up duration was not sufficient to detect potential differences in overall survival. Eight years later this has changed, and a significant overall survival benefit could be detected in favor of regional hyperthermia.

>Click here to read the rest of the interview regarding the JAMA Oncology publication

Infografik SSTS