PYREXAR HyperThermia (HT) systems deliver therapeutic heating via non invasive radio frequency (RF) energy in the 75-140 MHz range (BSD-500 delivers at a fixed 915 MHz) During PYREXAR HT treatment, the cancerous tumor is gently warmed to 40˚-45˚C (104˚-113˚F) destroying malignant cells while preserving normal tissues. This is because higher temperatures selectively damage cells that are hypoxic and have a low pH, a condition of cancer cells that is not present in normal cells.
The BSD-500 Superficial is a versatile, fully self-contained treatment system in a mobile configuration for maximum treatment flexibility of superficial tumors (within 1” of skin surface).
- Generator: 915 MHz / 0-400 Watts total power and 0-60 Watts per channel / 8 Channels (no RF shielding required).
- Wave Guides: Three (3) external wave guide applicators for direct energy application to solid surface tumors (MA-120, MA-151, MA-100), including overhead suspension adjustable arm system.
- Thermometry: Eight (8) ports for thermistor type sensors, sensor simulator and thermal probe calibration well.
- Workstation: Integrated PC with treatment planning software and touch screen monitor
Interstitial hyperthermia delivers heat directly to a tumor using arrays of up to 24 independent,flexible dipole antenna wires energized with eight (8) independent power channels.
Interstitial therapy capabilities are incorporated into the BSD-500.
The BSD-500i is a standalone interstitial therapy system configured similar to the BSD-500 but without external wave guides and supporting apparatus. The BSD-500 is the most popular PYREXAR HT system with more than 50 in clinical use throughout the US.
The BSD-2000 series systems use an annular phased array configuration of up to 8 diapole antennas to shape and focus thermal energy on targeted treatment area deep inside the pelvis, abdomen, limbs or chest with 2D electronic focal steering with the 4 channel RF power generator. (Note this is for the Sigma Eye in Europe. The applicator arrays in the U.S. only provides up to 8 dipole antennas.)
- Generator: 75 – 140 MHz / 0–325 or 0-450 Watts per channel / 4 Channels for BSD-2008B and BSD-2000U (RF shielding required).
- Phased Array Dipole Applicators: Sigma Elipse and Sigma 60 (standard); Sigma 40/30 (optional in some countries).
- Sigma Base: Comfortably positions and supports patient on sling inside phased array aperture.
- Thermometry: Eight (8) ports for thermistor type sensors, sensor simulator and thermal probe calibration bath.
- Workstation: PC with treatment planning software and touch screen monitor.
BSD-2000 3D additionally includes:
- Sigma Eye with 24 dipole antenna with 8 dipoles per annular ring to provide 3D electronic focus steering using 12 RF power channels. Can also be used with the other phased array applicators.
BSD-2000 3D/ MRI additionally includes:
- Integration with 1.5 Tesla MR system (instead of Sigma Base).
- MR image guided real-time non-invasive thermometry
Generator for BSD-2000
The generator develops high frequency electrical power output from a conventional three phase 415Vac source with multi-channel independent phase and amplitude adjustment capability. An integrated computer controls forward and reflected power, phase and power level on each channel. Frequency range of 75-140MHz.
Generator for BSD-500
The generator develops high frequency electrical power output from a conventional single phase 115/220Vac source with multi-channel independent phase and amplitude adjustment capability. An integrated computer controls forward and reflected power, phase and power level on each channel. Frequency 915MHz.
BSD-500 Wave Guides
Using electrical signal from generator, the wave guide creates and projects the RF energy beam toward the treatment area. Tissue absorption of this energy beam causes warming by tissue excitation.
BSD-500 Single Source (915 MHz):
|Model||Aperture (cm)||Treatment Field (cm)||Typical Power (Watts)||Configuration|
|MA-100||10"Wx13"L||8"Wx10"L x 2.5" deep||100||Side-loaded|
|MA-120||18"Wx24"L||12.5"Wx19.5"L x 2.5" deep||250||Side-loaded|
|MA-151||4"Wx5"L||2.5"Wx2.5"Lx 2.0" deep||40||Mini-Dual Ridge|
BSD-2000 Annular Phased Array (75 – 140 MHz):
|30||13||1||4||8||Circular / single array|
|Sigma 60||60||20||1||4||8||Circular / single ring array|
|Sigma Elipse||60||20||1||4||8||Circular / single ring array|
|54"Wx37"H||20||3||12||24||Ellipsoidal / triple ring array
|54"Wx37"H||20||3||12||24||Ellipsoidal / triple ring array
Interstitial Coaxial Wire (915 MHz):
The MA-251 is a semi-rigid 15.5 gauge wire coaxial cable providing an ellipsoidal heating pattern approximately 4.5 cm in length along the applicator shaft with heating to the wire tip.
The MA-251 fits inside 5F catheters commonly used for brachytherapy.
Annular Phase Array wave guides use non-ISM frequencies and require RF shielding. Single Source and Interstitial Wire wave guides use the Industrial, Scientific and Medical (ISM) radio band (915 MHz) and do not require RF Shielding.
Water filled bolus on wave guide surface provides dielectric load and energy-confining medium.
- Modes: Fill, Drain, Circulate, Heat, and Cooling.
- Temperature Range: 25°C to 40°C
Sigma Base (BSD-2000)
The Sigma treatment base provides comfortable patient positioning and thorax-to-toe array aperture location possibilities.
- Hydraulic patient elevation/tilt.
- Dielectric patient isolation.
- Integrated hot and cold water reservoirs with quick drain capability.
All BSD-500 components are self-contained in a portable unit on swivel-locking casters with generator and computer assembly securely rack mounted. The rotating thermometry interface, thermal well, and interstitial coaxial wire cable applicator interface panel is oriented for easy access. The waveguide applicator support arm is mounted on a column that provides overhead suspension for superficial treatment waveguides applicators.
- Foot Print: 60 x 60cm (24” x 24”)
- Power Requirement: 115-230VAC +/-10% | 50-60 Hz | Current consumption < 10 amps
Tumor tissue is monitored throughout treatment with temperature probes placed in interstitial catheters and/or nearby body cavities. PYREXAR HT systems use up to eight (8) TMP110 inherently stable thermistor type sensors that are non-perturbing and electromagnetically insensitive.
- Sensor diameter is approximately 1.1mm and is located at one end of a 33 cm (13 inch)lead.
- Accuracy: +/- 0.2˚C over a range of 25 to 52˚C.
- Automated positioning system with the BSD-2000 allows Thermal Mapping along catheter length to measure and monitor temperature profile throughout tumor tissue.
- An integrated probe calibration system is accurate to +/- 0.05˚C over a range of 0 to 60˚C is provided with the BSD-2000 and an integral thermal well is provided wth the BSD-500.
The BSD-2000 3D/MRI employs real-time MR image guided non-invasive thermometry using proton resonance frequency shift measurements, accurate within +/- 0.5˚C.
Treatment Control Workstation for both BSD-2000 and BSD-500
Treatments are planned and managed at a PC based workstation. Closed-loop feedback system provides automatic monitoring and control of treatment parameters including power output,frequency (BSD-500 is fixed at 915MHz), amplitude and phase, tissue temperatures, core temperature and treatment time.
- User friendly, intuitive, color graphics interface with touch screen control. (Note touch screen control is in process for BSD-2000)
- Step-by-step guide for setup and treatment procedure.
- Icon selectable adjustments of treatment parameters.
- System automatically records, displays and prints patient treatment data.
- Numerous checks are automatically performed to ensure safety for patient and operator.